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Pheromone effect of estradiol regulates the conjugative transfer of pCF10 carrying antibiotic resistance genes by Xiaobo Yang; Yuanyuan Niu; Yutong Yang; Hongrui Zhou; Jing Li; Xinyue Fu; Zhiqiang Shen; Jingfeng Wang; Zhigang Qiu is a Environmental Science article available to read on EtoBox.
What is Pheromone effect of estradiol regulates the conjugative transfer of pCF10 carrying antibiotic resistance genes about?
Horizontal gene transfer (HGT) mediated by conjugative plasmids greatly contributes to bacteria evolution and the transmission of antibiotic resistance genes (ARGs). In addition to the selective pressure imposed by extensive antibiotic use, environmental chemical pollutants facilitate the dissemination of antibiotic resistance, consequently posing a serious threat to the ecological environment. Presently, the majority of studies focus on the effects of environmental compounds on R plasmid-mediated conjugation transfer, and pheromone-inducible conjugation has largely been neglected. In this study, we explored the pheromone effect and potential molecular mechanisms of estradiol in promoting the conjugative transfer of pCF10 plasmid in Enterococcus faecalis. Environmentally relevant concentrations of estradiol significantly increased the conjugative transfer of pCF10 with a maximum frequency of 3.2 × 10-2, up to 3.5-fold change compared to that of control. Exposure to estradiol induced the activation of pheromone signaling cascade by increasing the expression of ccfA. Furthermore, estradiol might directly bind to the pheromone receptor PrgZ and promote pCF10 induction and finally enha
Who reads Pheromone effect of estradiol regulates the conjugative transfer of pCF10 carrying antibiotic resistance genes?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Xiaobo Yang; Yuanyuan Niu; Yutong Yang; Hongrui Zhou; Jing Li; Xinyue Fu; Zhiqiang Shen; Jingfeng Wang; Zhigang Qiu
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Environmental Science (Physical Sciences)