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Can I read Preparative and Analytical High-performance Liquid Chromatographic Methods in the Systhesis and Analysis of Decomposition of Nitrosourea Nucleosides on EtoBox?
Preparative and Analytical High-performance Liquid Chromatographic Methods in the Systhesis and Analysis of Decomposition of Nitrosourea Nucleosides by W.F. Brubaker Jr.; W.H. Prusoff is a Chemistry article available to read on EtoBox.
What is Preparative and Analytical High-performance Liquid Chromatographic Methods in the Systhesis and Analysis of Decomposition of Nitrosourea Nucleosides about?
Details are given for reversed-phase, adsorption, and aqueous ammonia-modified adsorption high-performance liquid chromatographic systems developed to separate 3'-chloroethylnitrosourea analogues of thymidine, 2'-deoxyuridine, and S-fluoro-2'-deoxyuridine from their decomposition products and synthetic precursors. The effect of varying the substituent at the 3'-and 5position on relative retention in each system is discussed. These systems are used to purify intermediates in the synthesis of these potent antineoplastic agents, and for the simultaneous analysis of the nitrosourea nucleosides and their breakdown products in kinetic studies of their decomposition. Application of these methods to the analysis of the kinetics of the breakdown of these compounds is demonstrated, with detection limits (signal-tonoise ratio = 2) in the l-2 ng range.
Who reads Preparative and Analytical High-performance Liquid Chromatographic Methods in the Systhesis and Analysis of Decomposition of Nitrosourea Nucleosides?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- W.F. Brubaker Jr.; W.H. Prusoff
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-3778)
- Published
- 1985
- Language
- EN
- Field
- Chemistry (Physical Sciences)