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Low holotranscobalamin II is the earliest serum marker for subnormal vitamin B~12~ (cobalamin) absorption in patients with AIDS by Victor Herbert; Warren Fong; Veronica Gulle; Tracy Stopler is a Medicine article available to read on EtoBox.

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In AIDS, as previously found in pernicious anemia (PA), the earliest serum marker of subnormal vitamin B, , (cobalamin) absorption, and therefore of negative B, , balance, is low serum holotranscobalamin II (holo-TC II; B,,-TC II) despite normal total serum B, , level, normal serum homocysteine, and normal classic (oral free radio-B,,) Schilling test. This may be accompanied by subtle and insidious damage to hematopoietic, immunologic, neuropsychiatric, nutritional and alimentary systems, confirmed by correction on therapeutic trial with B, , therapy. Our studies suggest such selective B,, deficiency occurs in about half of the HIV-1 infected, in part due to frequent depression of B, , absorption by HIV-1 attack on the gastric mucosa and/or opportunistic infection attack on the small bowel, and in part due to a telescoping of the continuum of the stages of negative B, , balance in relation to damage to B, , delivery by the infective and/or systemic disease process. In AIDS, when total serum B, , is normal despite tissue depletion of B,,, if the classic Schilling test does not reveal subnormal food B, , absorption, the food Schilling test does. We hypothesize that DNA-synthesizing c

Who reads Low holotranscobalamin II is the earliest serum marker for subnormal vitamin B~12~ (cobalamin) absorption in patients with AIDS?

Author

Victor Herbert; Warren Fong; Veronica Gulle; Tracy Stopler

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0361-8609)

Published

1990

Language

EN

Field

Medicine (Health Sciences)