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β-lactam antibiotic-induced release of lipoteichoic acid from Staphylococcus aureus leads to activation of neutrophil granulocytes by Sonja Lotz; Andrea Starke; Christian Ziemann; Siegfried Morath; Thomas Hartung; Werner Solbach; Tamás Laskay is a Medicine article available to read on EtoBox.

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## Background Polymorphonuclear neutrophil granulocytes (PMN) are phagocytes of the first line of antimicrobial defense. Previously we demonstrated that lipoteichoic acid (LTA) from __Staphylococcus aureus__ (__S. aureus__) directly activates neutrophil granulocytes. Others have reported that exposure of __S. aureus__ to β-lactam antibiotics leads to LTA release. In the present study we addressed the question whether exposure of __S. aureus__ to β-lactam antibiotics or antibiotics of other groups results in the generation of PMN-stimulating activity and whether this activity can be attributed to LTA. ## Methods __S. aureus__ were exposed to flucloxacillin, a β-lactam antibiotic or to the protein synthesis-inhibitors erythromycin and gentamicin, or to ciprofloxacin, a gyrase inhibitor. Supernatants of the antibiotic-treated bacteria were assayed for their LTA content and for their effect on PMN functions. ## Results We observed that exposure of __S. aureus__ to flucloxacillin and, to a lesser degree to ciprofloxacin, but not to erythromycin or gentamicin led to LTA release. Co-incubation of neutrophil granulocytes with LTA-containing supernatants led to PMN activation as assed by mo

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Author

Sonja Lotz; Andrea Starke; Christian Ziemann; Siegfried Morath; Thomas Hartung; Werner Solbach; Tamás Laskay

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, [2002]-; Springer Science and Business Media LLC; Springer Nature (ISSN 1476-0711)

Published

2006

Language

EN

Field

Medicine (Health Sciences)