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Can I read Off the shelf cellular therapeutics: Factors to consider during cryopreservation and storage of human cells for clinical use on EtoBox?
Off the shelf cellular therapeutics: Factors to consider during cryopreservation and storage of human cells for clinical use by Erik J. Woods; Sreedhar Thirumala; Sandhya S. Badhe-Buchanan; Dominic Clarke; Aby J. Mathew is a Medicine article available to read on EtoBox.
What is Off the shelf cellular therapeutics: Factors to consider during cryopreservation and storage of human cells for clinical use about?
The field of cellular therapeutics has immense potential, affording an exciting array of applications in unmet medical needs. One of several key issues is an emphasis on getting these therapies from bench to bedside without compromising safety and efficacy. The successful commercialization of cellular therapeutics will require many to extend the shelf-life of these therapies beyond shipping "fresh" at ambient or chilled temperatures for "just in time" infusion. Cryopreservation is an attractive option and offers potential advantages, such as storing and retaining patient samples in case of a relapse, banking large quantities of allogeneic cells for broader distribution and use and retaining testing samples for leukocyte antigen typing and matching. However, cryopreservation is only useful if cells can be reanimated to physiological life with negligible loss of viability and functionality. Also critical is the logistics of storing, processing and transporting cells in clinically appropriate packaging systems and storage devices consistent with quality and regulatory standards. Rationalized approaches to develop commercial-scale cell therapies require an efficient cryopreservation sy
Who reads Off the shelf cellular therapeutics: Factors to consider during cryopreservation and storage of human cells for clinical use?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Erik J. Woods; Sreedhar Thirumala; Sandhya S. Badhe-Buchanan; Dominic Clarke; Aby J. Mathew
- Publisher
- Elsevier BV
- Published
- 2016
- Language
- EN
- Field
- Medicine (Health Sciences)