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Genetic and Racial Differences in the Vitamin D Endocrine System by Roger Bouillon is a Medicine article available to read on EtoBox.

What is Genetic and Racial Differences in the Vitamin D Endocrine System about?

Vitamin D is essential for calcium and bone homeostasis and may have many other nonskeletal effects. [1][2][3][4] The "nutritional status" of vitamin D is usually assessed by measurements of serum 25-hydroxyvitamin D (25OHD), because this reflects the access to either exogenous (food) or endogenous (skin) synthesis of the parent vitamin D. Indeed, most of the supply of vitamin D is rapidly cleared from serum and is metabolized into 25OHD, with an estimated conversion efficacy of about 25% to 33%, as based on comparison between vitamin D status after oral intake of the parent vitamin D or 25OHD. 5,6 The hormonal status of vitamin D is reflected in serum concentrations of 1,25(OH) 2 D as the renal conversion of 25OHD into 1,25(OH) 2 D is tightly feedbackcontrolled by several hormones. [1][2][3][4] The paracrine/autocrine status of vitamin D, being the local conversion of 25OHD into 1,25(OH) 2 D in several tissues by locally expressed CYP27B1, so far cannot be easily assessed. From several twin studies, one can The author received speakers fee from Amgen, Abiogen, L'Ore `al, Chugai and Teijin and is co-owner of a university patent on vitamin D analogs licenced to Hybrigenix (France).

Who reads Genetic and Racial Differences in the Vitamin D Endocrine System?

Author

Roger Bouillon

Publisher

Elsevier BV

Published

2017

Language

EN

Field

Medicine (Health Sciences)