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Can I read Chemical Inducers and Transcriptional Markers of Oligodendrocyte Differentiation on EtoBox?
Chemical Inducers and Transcriptional Markers of Oligodendrocyte Differentiation by Lara Joubert; Isabelle Foucault; Yves Sagot; Lilia Bernasconi; François Duval; Chantal Alliod; Marie‐José Frossard; Rosanna Pescini Gobert; Marie‐Laure Curchod; Catherine Salvat; Anthony Nichols; Sandrine Pouly; Christian Rommel; Arthur Roach; Rob Hooft van Huijsduijnen is a Neuroscience article available to read on EtoBox.
What is Chemical Inducers and Transcriptional Markers of Oligodendrocyte Differentiation about?
## Abstract Oligodendrocytes generate and maintain myelin, which is essential for axonal function and protection of the mammalian central nervous system. To advance our molecular understanding of differentiation by these cells, we screened libraries of pharmacologically active compounds and identified inducers of differentiation of Oli‐neu, a stable cell line of mouse oligodendrocyte precursors (OPCs). We identified four broad classes of inducers, namely, forskolin/cAMP (protein kinase A activators), steroids (glucocorticoids and retinoic acid), ErbB2 inhibitors, and nucleoside analogs, and confirmed the activity of these compounds on rat primary oligodendrocyte precursors and mixed cortical cultures. We also analyzed transcriptional responses in the chemically induced mouse and rat OPC differentiation processes and compared these with earlier studies. We confirm the view that ErbB2 is a natural signaling component that is required for OPC proliferation, whereas ErbB2 inhibition or genetic knockdown results in OPC differentiation. © 2010 Wiley‐Liss, Inc.
Who reads Chemical Inducers and Transcriptional Markers of Oligodendrocyte Differentiation?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Lara Joubert; Isabelle Foucault; Yves Sagot; Lilia Bernasconi; François Duval; Chantal Alliod; Marie‐José Frossard; Rosanna Pescini Gobert; Marie‐Laure Curchod; Catherine Salvat; Anthony Nichols; Sandrine Pouly; Christian Rommel; Arthur Roach; Rob Hooft van Huijsduijnen
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 2010
- Language
- EN
- Field
- Neuroscience (Life Sciences)