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Dexamethasone Sodium Phosphate Penetration During Phonophoresis at Two Ultrasound Frequencies by Rigby, Justin H.; Hagan, Austin M.; Kelcher, Austin R.; Ji, Chang is a Medicine article available to read on EtoBox.

What is Dexamethasone Sodium Phosphate Penetration During Phonophoresis at Two Ultrasound Frequencies about?

## Context The effect of ultrasound frequency on phonophoresis drug delivery in humans is unknown. ## Objective To determine if a low (45-kHz) or high (1-MHz) frequency delivered a higher dexamethasone (Dex) concentration through the skin. ## Design Controlled laboratory study. ## Setting Laboratory. ## Patients or Other Participants A total of 40 healthy men between the ages of 18 and 45 years (age = 23.1 ± 2.6 years, height = 176.1 ± 7.2 cm, mass = 88.5 ± 19.4 kg, posterior calf subcutaneous thickness measured using musculoskeletal ultrasound imaging = 0.6 ± 0.2 cm). ## Intervention(s) Participants were randomly assigned to 1 of 4 groups (ultrasound frequency at microdialysis probe depth): (1) 45-kHz frequency at 1 mm, (2) 45-kHz frequency at 4 mm, (3) 1-MHz frequency at 1 mm, or (4) 1-MHz frequency at 4 mm (n = 10 in each group). Three linear microdialysis probes were inserted at the desired tissue depth. We rubbed dexamethasone sodium phosphate (Dex-P) into the skin and then applied a 15-minute phonophoresis treatment. ## Main Outcome Measure(s) Dialysate was collected during the treatment and 60 minutes posttreatment and analyzed for Dex-P, Dex, and the metabolite form of Dex.

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Author

Rigby, Justin H.; Hagan, Austin M.; Kelcher, Austin R.; Ji, Chang

Publisher

National Athletic Trainers Association; Journal of Athletic Training/NATA; National Athletic Trainers Association, Inc.; Dallas TX: National Athletic Trainers' Association (ISSN 1062-6050)

Published

2020

Language

EN

ISBN

9781062605051

Field

Medicine (Health Sciences)