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Expression of Cytokeratin Polypeptides During Development of the Rat Inner Ear by W. Kuijpers; T. A. Peters; E. L. G. M. Tonnaer; F. C. S. Ramaekers is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Expression of Cytokeratin Polypeptides During Development of the Rat Inner Ear about?

The expression of cytokeratin polypeptides in the different epithelia of the developing inner ear of the rat from 12 days post conception to 20 days after birth was analysed immunohistochemically, using a panel of monoclonal antibodies. Throughout the development of the complex epithelial lining of the inner ear originating from the otocyst epithelium, only cytokeratins which are typical of simple epithelia were expressed. Cytokeratins 8, 18, and 19 were detectable shortly after the formation of the otocyst from the ectoderm (12 dpc), whereas cytokeratin 7 expression was delayed and first appeared in the vestibular portion and subsequently in the developing cochlear duct. During the development of the different types of specialized cells, differentiation-dependent modulation of the cytokeratin expression patterns was observed. In the mature inner ear, the specialized cell types displayed a function-related cytokeratin expression profile, both in the cochlear and vestibular portion. Cytokeratin expression in the flat epithelium of the vestibular portion suggests a more complex composition of this epithelium than has been established from routine morphology. Remarkably, the cochlear

Who reads Expression of Cytokeratin Polypeptides During Development of the Rat Inner Ear?

Author

W. Kuijpers; T. A. Peters; E. L. G. M. Tonnaer; F. C. S. Ramaekers

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 1432-119X)

Published

1991

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)