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DNA methylation is associated with airflow obstruction in patients living with HIV by Ana I Hernandez Cordero; Chen Xi Yang; Maen Obeidat; Julia Yang; Julie MacIsaac; Lisa McEwen; David Lin; Michael Kobor; Richard Novak; Fleur Hudson; Hartwig Klinker; Nila Dharan; SF Paul Man; Don D Sin; Ken Kunisaki; Janice Leung is a Medicine article available to read on EtoBox.
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## Introduction: People living with hiv (plwh) suffer from age-related comorbidities such as copd. the processes responsible for reduced lung function in plwh are largely unknown. we performed an epigenome-wide association study to investigate whether blood dna methylation is associated with impaired lung function in plwh. ## Methods: Using blood dna methylation profiles from 161 plwh, we tested the effect of methylation on fev, fev/fvc ratio and fev decline over a median of 5 years. we evaluated the global methylation of plwh with airflow obstruction by testing the differential methylation of transposable elements alu and line-1, a well-described marker of epigenetic ageing. ## Results: Airflow obstruction as defined by a fev/fvc<0.70 was associated with 1393 differentially methylated positions (dmps), while 4676 were associated with airflow obstruction based on the fev/fvc ## Conclusion: A large number of dmps were associated with airflow obstruction and lung function in a unique cohort of plwh. airflow obstruction in even relatively young plwh is associated with global hypomethylation, suggesting advanced epigenetic ageing compared with those with normal lung function. the distu
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- Author
- Ana I Hernandez Cordero; Chen Xi Yang; Maen Obeidat; Julia Yang; Julie MacIsaac; Lisa McEwen; David Lin; Michael Kobor; Richard Novak; Fleur Hudson; Hartwig Klinker; Nila Dharan; SF Paul Man; Don D Sin; Ken Kunisaki; Janice Leung
- Publisher
- BMJ Publishing Group
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)