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Can I read The Effect of Storage on the Expression of Platelet Membrane Phosphatidylserine and the Subsequent Impacton the Coagulant Function of Stored Platelets on EtoBox?
The Effect of Storage on the Expression of Platelet Membrane Phosphatidylserine and the Subsequent Impacton the Coagulant Function of Stored Platelets by Shirley Shapira; Ziva Friedman; Hava Shapiro; Katya Presseizen; Judith Radnay; Martin H. Ellis is a Medicine article available to read on EtoBox.
What is The Effect of Storage on the Expression of Platelet Membrane Phosphatidylserine and the Subsequent Impacton the Coagulant Function of Stored Platelets about?
**BACKGROUND:** Platelet concentrates (PCs) derived from whole blood and stored under standard blood bank conditions undergo changes that are referred to as the platelet storage lesion. This study assesses the effect of PC preparation and storage on the distribution of phosphatidylserine (PS) in the platelet membrane and the effect that this distribution may have on the thrombogenic potential of stored PCs. **STUDY DESIGN AND METHODS:** Fresh platelets and PCs donated by healthy donors were obtained. PCs derived from platelet‐rich plasma were studied on Day 1, Day 3, and Day 6 of storage under blood bank conditions. **RESULTS:** Platelet aggregation after exposure to the platelet agonists ADP and epinephrine singly declined progressively, but, when ADP and epinephrine in combination and collagen and thrombin in combination were used as agonists, the decline in platelet aggregation was less marked. PS expression as measured by Annexin V binding (mean and SD) was 2.02 ± 0.93 percent in fresh platelet samples and increased to 5.39 ± 4.2 percent on Day 1, 22.1 ± 7.1 percent on Day 3, and 39.5 ± 12.1 percent on Day 6. Platelet prothrombinase activity (mean ± SD) as measured by thrombin
Who reads The Effect of Storage on the Expression of Platelet Membrane Phosphatidylserine and the Subsequent Impacton the Coagulant Function of Stored Platelets?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Shirley Shapira; Ziva Friedman; Hava Shapiro; Katya Presseizen; Judith Radnay; Martin H. Ellis
- Publisher
- Elsevier Science; John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Elsevier; Elsevier BV; Wiley (ISSN 0372-1248)
- Published
- 2000
- Language
- EN
- Field
- Medicine (Health Sciences)