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Can I read Multimodal Biomarkers Quantify Recovery in Autoimmune Autonomic Ganglionopathy on EtoBox?
Multimodal Biomarkers Quantify Recovery in Autoimmune Autonomic Ganglionopathy by Shiwen Koay; Ekawat Vichayanrat; Fion Bremner; Jalesh N. Panicker; Bethan Lang; Michael P. Lunn; Laura Watson; Gordon T. Ingle; Ellen Merete Hagen; Patricia McNamara; Leslie Jacobson; Vincenzo Provitera; Maria Nolano; Angela Vincent; Christopher J. Mathias; Valeria Iodice is a Medicine article available to read on EtoBox.
What is Multimodal Biomarkers Quantify Recovery in Autoimmune Autonomic Ganglionopathy about?
Objective: The objective of this study was to evaluate patients with ganglionic acetylcholine receptor antibody (gAChR-Ab) positive autoimmune autonomic ganglionopathy using a multimodal testing protocol to characterize their full clinical phenotype and explore biomarkers to quantify immunotherapy response. Methods: We conducted a cohort study of 13 individuals (7 women, 21-69 years of age) with autonomic failure and gAChR-Ab >100 pM identified between 2005 and 2019. From 2018, all patients were longitudinally assessed with cardiovascular, pupillary, urinary, sudomotor, lacrimal and salivary testing, and Composite Autonomic Symptom Score (COMPASS-31) autonomic symptom questionnaires. The orthostatic intolerance ratio was calculated by dividing change in systolic blood pressure over time tolerated on head-up tilt. Eleven patients received immunotherapy. Results: At first assessment, all 13 patients had cardiovascular and pupillary impairments, 7 of 8 had postganglionic sudomotor dysfunction, 9 of 11 had urinary retention and xeropthalmia, and 6 of 8 had xerostomia. After immunotherapy, there were significant improvements in orthostatic intolerance ratio (33.3 [17.8-61.3] to 5.2 [1.4
Who reads Multimodal Biomarkers Quantify Recovery in Autoimmune Autonomic Ganglionopathy?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Shiwen Koay; Ekawat Vichayanrat; Fion Bremner; Jalesh N. Panicker; Bethan Lang; Michael P. Lunn; Laura Watson; Gordon T. Ingle; Ellen Merete Hagen; Patricia McNamara; Leslie Jacobson; Vincenzo Provitera; Maria Nolano; Angela Vincent; Christopher J. Mathias; Valeria Iodice
- Publisher
- Wiley
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)