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Anlotinib Inhibits Proliferation and Induces Apoptosis in B-cell Acute Lymphoblastic by Xiaowei Shi; Shuangyue Li; Shanhao Tang; Ying Lu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Anlotinib Inhibits Proliferation and Induces Apoptosis in B-cell Acute Lymphoblastic about?

## Background: Acute lymphoblastic leukemia (ALL) is the second most common acute leukemia in adults, whose known drug treatments are limited and expensive. ## Objective: This investigation aimed to investigate the therapeutic potential of anlotinib in B-cell acute lymphoblastic leukemia (B-ALL). ## Methods: The B-ALL cell lines Nalm-6 and BALL-1 were used to verify the therapeutic potential of anlotinib in BALL. The cell activity was measured by Cell Counting Kit-8. Apoptosis was detected by Annexin V-FITC/PI double staining combined with flow cytometry. Afterward, the binding capacity of anlotinib to the critical protein was predicted by molecular docking, and the protein changes in the related pathways downstream of the target proteins were verified by western blot. Finally, the effect of anlotinib on the survival rate was verified in B-ALL nude mice. ## Results: Anlotinib inhibited the proliferation of the B-ALL cell lines, Nalm-6, and BALL-1, and promoted apoptosis. Molecular docking results showed that it had the potential binding ability to BTK. Western blot revealed that anlotinib was able to inhibit the phosphorylation of BTK, AKT, and mTOR, thereby inhibiting the prolifer

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Author

Xiaowei Shi; Shuangyue Li; Shanhao Tang; Ying Lu

Publisher

Bentham Science Publishers Ltd.

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)