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Aberrant synaptic transmission in the hippocampal CA3 region and cognitive deterioration in protein-repair enzyme-deficient mice by Yuji Ikegaya; Mitsunori Yamada; Tetsuya Fukuda; Hidehito Kuroyanagi; Takuji Shirasawa; Nobuyoshi Nishiyama is a Neuroscience article available to read on EtoBox.
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## Abstract L‐aspartate is the amino‐acid residue most susceptible to spontaneous isomerization. This denaturation causes an alteration in the biological activity of the protein and is regarded as an aging process of the protein. Protein L‐isoaspartyl methyltransferase (PIMT) repairs this posttranslational modification and thus is implicated in retarding the aging process of proteins. PIMT is highly expressed in the brain, and its deficiency results in progressive epilepsy after 4 weeks of age, with a fatal seizure in mice. Here we report the pathophysiological role of this repair system in the hippocampal slice of PIMT‐deficient mice. The hippocampal mossy fiber‐CA3 synapses of PIMT‐deficient mice showed hyperexcitation that was repressed by a γ‐aminobutyric acid (GABA)~A~ receptor agonist muscimol. In addition, the mossy fiber‐CA3 synapses failed to show long‐term potentiation or paired‐pulse facilitation. No abnormality, however, was observed in Schaffer collateral‐CA1 synapses or in perforant path‐dentate gyrus synapses. Electron microscopic study revealed aberrant distribution of synaptic vesicles in the mossy fiber terminals and vacuolar degeneration at the axon hillock of de
Who reads Aberrant synaptic transmission in the hippocampal CA3 region and cognitive deterioration in protein-repair enzyme-deficient mice?
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- Author
- Yuji Ikegaya; Mitsunori Yamada; Tetsuya Fukuda; Hidehito Kuroyanagi; Takuji Shirasawa; Nobuyoshi Nishiyama
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1050-9631)
- Published
- 2001
- Language
- EN
- Field
- Neuroscience (Life Sciences)