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Reversal of Profound Vecuronium-induced Neuromuscular Block Under Sevoflurane Anesthesia: Sugammadex Versus Neostigmine by Hendrikus JM Lemmens; Mohammad I El-Orbany; James Berry; Jovino Ben Morte; Gavin Martin is a Medicine article available to read on EtoBox.

What is Reversal of Profound Vecuronium-induced Neuromuscular Block Under Sevoflurane Anesthesia: Sugammadex Versus Neostigmine about?

Background: Acetylcholinesterase inhibitors cannot rapidly reverse profound neuromuscular block. Sugammadex, a selective relaxant binding agent, reverses the effects of rocuronium and vecuronium by encapsulation. This study assessed the efficacy of sugammadex compared with neostigmine in reversal of profound vecuronium-induced neuromuscular block under sevoflurane anesthesia. Methods: Patients aged ≥18 years, American Society of Anesthesiologists class 1-4, scheduled to undergo surgery under general anesthesia were enrolled in this phase III, multicenter, randomized, safety-assessor blinded study. Sevoflurane anesthetized patients received vecuronium 0.1 mg/kg for intubation, with maintenance doses of 0.015 mg/kg as required. Patients were randomized to receive sugammadex 4 mg/kg or neostigmine 70 μg/kg with glycopyrrolate 14 μg/kg at 1-2 post-tetanic counts. The primary efficacy variable was time from start of study drug administration to recovery of the train-of-four ratio to 0.9. Safety assessments included physical examination, laboratory data, vital signs, and adverse events. Results: Eighty three patients were included in the intent-to-treat population (sugammadex, n = 47; ne

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Author

Hendrikus JM Lemmens; Mohammad I El-Orbany; James Berry; Jovino Ben Morte; Gavin Martin

Publisher

BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, 2001-; Springer Science and Business Media LLC (ISSN 1471-2253)

Published

2010

Language

EN

Field

Medicine (Health Sciences)