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TRYBE®: an Fc-free antibody format with three monovalent targeting arms engineered for long in vivo half-life by Emma Davé; Oliver Durrant; Neha Dhami; Joanne Compson; Janice Broadbridge; Sophie Archer; Asher Maroof; Kevin Whale; Karelle Menochet; Pierre Bonnaillie; Emily Barry; Gavin Wild; Claude Peerboom; Pallavi Bhatta; Mark Ellis; Matthew Hinchliffe; David P. Humphreys; Sam P. Heywood is a Medicine article available to read on EtoBox.
What is TRYBE®: an Fc-free antibody format with three monovalent targeting arms engineered for long in vivo half-life about?
## ABSTRACT TrYbe® is an Fc-free therapeutic antibody format, capable of engaging up to three targets simultaneously, with long __in vivo__ half-life conferred by albumin binding. This format is shown by small-angle X-ray scattering to be conformationally flexible with favorable ‘reach’ properties. We demonstrate the format’s broad functionality by co-targeting of soluble and cell surface antigens. The benefit of monovalent target binding is illustrated by the lack of formation of large immune complexes when co-targeting multivalent antigens. TrYbes® are manufactured using standard mammalian cell culture and protein A affinity capture processes. TrYbes® have been formulated at high concentrations and have favorable drug-like properties, including stability, solubility, and low viscosity. The unique functionality and inherent developability of the TrYbe® makes it a promising multi-specific antibody fragment format for antibody therapy.
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- Author
- Emma Davé; Oliver Durrant; Neha Dhami; Joanne Compson; Janice Broadbridge; Sophie Archer; Asher Maroof; Kevin Whale; Karelle Menochet; Pierre Bonnaillie; Emily Barry; Gavin Wild; Claude Peerboom; Pallavi Bhatta; Mark Ellis; Matthew Hinchliffe; David P. Humphreys; Sam P. Heywood
- Publisher
- Informa UK Limited
- Published
- 2023
- Language
- EN
- Field
- Medicine (Life Sciences)