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Toll/Interleukin-1 receptor member ST2 exhibits higher soluble levels in type 2 diabetes, especially when accompanied with left ventricular diastolic dysfunction by Evangelos Fousteris; Andreas Melidonis; George Panoutsopoulos; Konstantinos Tzirogiannis; Stefanos Foussas; Anastasios Theodosis-Georgilas; Stavros Tzerefos; Spiridon Matsagos; Eleni Boutati; Theofanis Economopoulos; George Dimitriadis; Sotirios Raptis is a Medicine article available to read on EtoBox.
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## Background Soluble ST2, a member of the of the Toll/IL-1 superfamily, is a novel biomarker with exceptional predictive value in heart failure and myocardial infarction- related mortality as well as in acute dyspneic states. Soluble ST2 is considered a decoy receptor of IL 33 that blocks the protective effects of the cytokine in atherosclerosis and cardiac remodeling. In the present study we investigated the differences in the levels of soluble ST2, BNP and hs-CRP between healthy controls and patients with type 2 diabetes with and without left ventricular diastolic dysfunction. A secondary aim was to investigate correlations between sST2 and other biomarkers of type 2 diabetes, such as HbA1c. ## Methods 158 volunteers were recruited and underwent a complete Doppler-echocardiographic evaluation of both systolic & diastolic cardiac function. All subjects with ejection fraction < 50% were excluded. The study population was divided in 4 groups as follows: A: 42 healthy controls, B: 18 subjects without diabetes with LVDD, C: 48 patients with type 2 diabetes without LVDD & D: 50 patients with type 2 diabetes & LVDD. ELISA technique was performed to measure sST2 levels. Statistical anal
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- Author
- Evangelos Fousteris; Andreas Melidonis; George Panoutsopoulos; Konstantinos Tzirogiannis; Stefanos Foussas; Anastasios Theodosis-Georgilas; Stavros Tzerefos; Spiridon Matsagos; Eleni Boutati; Theofanis Economopoulos; George Dimitriadis; Sotirios Raptis
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2002-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1475-2840)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)