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Isotopic hydrogen exchange in the dinucleoside monophosphate IpI by G. J. Thomas Jr; S. A. Ferreira is a Chemistry article available to read on EtoBox.
What is Isotopic hydrogen exchange in the dinucleoside monophosphate IpI about?
## Abstract Each of the hypoxauthine residues of the dinucleoside monophosphate, inosylyl(3′→5′)inosine (IpI), manifests the same rate of deuterium exchange of the proton at the 8‐C ring position, as measured by Raman spectrophotometry. In the temperature interval 30–80°C and at neutral pD, the exchange rate constants yield Arrhenius parameters (__E__~a~ = 22.4±0.6 kcal mol^−1^; __A__ = 2.13 × 10^13^ h^−1^) that are identical to values obtained on inosine‐3′:5′‐monophosphate (cIMP), but different from those of inosine‐5′‐monophosphate (5′‐IMP) which exchanges more slowly. The results confirm that nucleotides containing the monovalent phosphate anion, exchange more rapidly than those containing the divalent phosphate anion, and suggest further that base stacking in IpI does not greatly retard the speed of 8‐CH exchange of either of the hypoxanthine rings.
Who reads Isotopic hydrogen exchange in the dinucleoside monophosphate IpI?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- G. J. Thomas Jr; S. A. Ferreira
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0377-0486)
- Published
- 1982
- Language
- EN
- Field
- Chemistry (Physical Sciences)