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Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1) by Michelle L. Holland; John D. Allen; Jonathon C. Arnold is a Neuroscience article available to read on EtoBox.

What is Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1) about?

The ATP-binding cassette (ABC) transporter ABCC1, or multidrug resistance-related protein 1 (MRP1) is implicated in Phase II metabolism and multidrug resistance as it effluxes substrate anticancer drugs. As cannabinoids inhibit two related ABC transporters, P-glycoprotein and ABCG2, here we examined whether they also inhibit ABCC1. Indeed, the cannabinoids enhanced the intracellular accumulation of two ABCC1 substrates, Fluo3 and vincristine, in ovarian carcinoma cells over-expressing ABCC1 (2008/MRP1) with a rank order of potency: cannabidiol N cannabinol N Δ 9 -tetrahydrocannabinol. Cannabinoid inhibition of ABCC1 was confirmed using insect cell membrane MRP1 ATPase assays. These results demonstrate that cannabinoids inhibit ABCC1.

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Author

Michelle L. Holland; John D. Allen; Jonathon C. Arnold

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0014-2999)

Published

2008

Language

EN

Field

Neuroscience (Life Sciences)