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Fructooligosaccharides (FOS) differentially modifies the in vitro gut microbiota in an age-dependent manner by Mahalak, Karley K. (author);Firrman, Jenni (author);Narrowe, Adrienne B. (author);Hu, Weiming (author);Jones, Steven M. (author);Bittinger, Kyle (author);Moustafa, Ahmed M. (author);Liu, LinShu (author) is a Medicine article available to read on EtoBox.
What is Fructooligosaccharides (FOS) differentially modifies the in vitro gut microbiota in an age-dependent manner about?
## Introduction Fructooligosaccharides (FOS) are well-known carbohydrates that promote healthy gut microbiota and have been previously demonstrated to enhance levels of __Bifidobacterium__ and __Lactobacillus__. Its bifidogenic properties are associated with positive health outcomes such as reduced obesity and anti-inflammatory properties, and, therefore, is in use as a prebiotic supplement to support healthy gut microbiota. However, the gut microbiota changes with age, which may lead to differential responses to treatments with prebiotics and other dietary supplements. ## Methods To address this concern, we implemented a 24-h __in vitro__ culturing method to determine whether FOS treatment in three different adult age groups would have a differential effect. The age groups of interest ranged from 25 to 70 years and were split into young adults, adults, and older adults for the purposes of this analysis. Metagenomics and short-chain fatty acid analysis were performed to determine changes in the structure and function of the microbial communities. ## Results These analyses found that FOS created a bifidogenic response in all age groups, increased overall SCFA levels, decreased alpha
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- Author
- Mahalak, Karley K. (author);Firrman, Jenni (author);Narrowe, Adrienne B. (author);Hu, Weiming (author);Jones, Steven M. (author);Bittinger, Kyle (author);Moustafa, Ahmed M. (author);Liu, LinShu (author)
- Publisher
- Frontiers Media SA
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)