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Activation of PD-1 Protects Intestinal Immune Defense Through IL-10/miR-155 Pathway After Intestinal Ischemia Reperfusion by Xu-Yu Zhang; Su Guan; Hu-Fei Zhang; Rui-Yun Li; Zi-Meng Liu is a Medicine article available to read on EtoBox.

What is Activation of PD-1 Protects Intestinal Immune Defense Through IL-10/miR-155 Pathway After Intestinal Ischemia Reperfusion about?

## Background: To date, mechanisms of intestinal immunoglobulin (ig) dysfunction following intestinal ischemia/reperfusion (i/r) remain unclear. programmed death 1 (pd-1) is associated with immune responses of lymphocytes. ## Aim: We aimed to verify the hypothesis that activation of pd-1 may improve intestinal immune dysfunction by regulating il-10/mir-155 production after intestinal ir injury. ## Methods: Intestinal i/r injury was induced in mice by clamping the superior mesenteric artery for 1 h followed by 2-h reperfusion. pd-l1 fusion ig, anti-interleukin (il)-10 monoclonal antibody (mab), and microrna (mir)-155 agomir were administered. pd-1 expression, il-10 mrna, and protein expression in peyer's patches (pp) cd4 cells were measured. mir-155 levels, tumor necrosis factor (tnf)-α and il-1β concentration, and activation-induced cytidine deaminase (aid), a key enzyme for intestinal immune antibodies, in pp tissues were measured, respectively. importantly, the production and cecal bacteria-binding capacity of iga and igm were detected. ## Results: Intestinal i/r led to decreased pd-1 expression, imbalanced production, and impaired bacteria-binding capacity of iga and igm. activa

Who reads Activation of PD-1 Protects Intestinal Immune Defense Through IL-10/miR-155 Pathway After Intestinal Ischemia Reperfusion?

Author

Xu-Yu Zhang; Su Guan; Hu-Fei Zhang; Rui-Yun Li; Zi-Meng Liu

Publisher

Springer US; Springer-Verlag; Kluwer Academic/Plenum Publishers; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0163-2116)

Published

2018

Language

EN

Field

Medicine (Health Sciences)