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A Possible Mechanism for Visible Light-induced Wound Healing by Anat Lipovsky; Yeshayahu Nitzan; Rachel Lubart is a Medicine article available to read on EtoBox.

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## Abstract ## Background and Objectives Chronic wounds resistant to conventional therapy have been treated successfully with low energy lasers and light emitting diodes (LEDs) in the visible and near IR region. It has been proposed that production of low level reactive oxygen species (ROS) following illumination is the first step of photobiomodulation. It was also shown that white light (400–800 nm) has similar stimulatory effects as lasers and LEDs. ROS at higher levels are toxic to cells and bacteria. ## Study Design/Materials and Methods In the present study, we examined the phototoxicity of broadband (400–800 nm, 120 J/cm^2^) visible light on the survival of several pathogenic bacteria: __Staphylococcus aureus 195__, __Pseudomonas aeruginosa 1316__, __Escherichia coli 1313__, and __Serratia marcescens__. These bacteria were chosen due to their high prevalence in infected wounds. The survival of bacterial cells following illumination was monitored by counting the number of colony forming units before and after exposure to light. ## Results Illumination with white light, 120 J/cm^2^, caused a reduction of 62%, 83%, and 56% in the colony count of __E. coli 1313__, __S. aureus 195

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Author

Anat Lipovsky; Yeshayahu Nitzan; Rachel Lubart

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0196-8092)

Published

2008

Language

EN

Field

Medicine (Health Sciences)