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This document describes the structure-based design and optimization of inhibitors for the adenoviral protease. The researchers designed a novel peptidomimetic scaffold to replace the P4-P3 amide bond in their initial tetrapeptide nitrile inhibitor. They also designed a complementary series of irreversible vinyl sulfone containing inhibitors. High resolution X-ray co-crystal structures of representatives from each inhibitor series confirmed the successful rational design and provided an excellent basis for f

Author

daniela

Language

EN