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133 Specificity of features of the bone marrow CD34+ cell fraction for the diagnosis of MDS by S.C. Reis-Alves; P.M. Campos; F.G. Pereira-Cunha; F. Traina; I. Lorand-Metze is a Medicine article available to read on EtoBox.

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Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis, peripheral cytopenias, and substantial risk for progression to acute myeloid leukemia. The chromosomal aberrations for MDS are well-known and are associated with good (-5/5q-, -Y, +8), poor (>3aberrations, chromosome 7), and intermediate prognosis (other). However, the frequency of aberrations detected by interphase FISH, karyotype, or both, and the frequency in each of the MDS subtypes as listed in the WHO 2008 classification, is not well documented. We identified 189 patients with a de novo MDS (by bone marrow morphology) between 2008-2010; 101 males and 88 females (9-93 years: median age 69). We analyzed the frequency of: (a) normal karyotype and normal FISH (59%), (b) normal karyotype and abnormal FISH (9%), (c) abnormal karyotype and abnormal FISH (16.4%), (d) abnormal karyotype and normal FISH (6.4%), and (e) abnormal karyotype only (10%) performed at a single institution. The following MDS subtypes were identified: Refractory cytopenias with unilineage dysplasia (RCUD) -2.6%, refractory anemia with ring sideroblasts (RARS) -0.5%, refractory anemia with mul

Who reads 133 Specificity of features of the bone marrow CD34+ cell fraction for the diagnosis of MDS?

Author

S.C. Reis-Alves; P.M. Campos; F.G. Pereira-Cunha; F. Traina; I. Lorand-Metze

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0145-2126)

Published

2011

Language

EN

Field

Medicine (Health Sciences)