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Targeting EGFR of triple-negative breast cancer enhances the therapeutic efficacy of paclitaxel- and cetuximab-conjugated nanodiamond nanocomposite by Wei-Siang Liao; Yu Ho; Yu-Wei Lin; Emmanuel Naveen Raj; Kuang-Kai Liu; Chinpiao Chen; Xiao-Zhen Zhou; Kun-Ping Lu; Jui-I Chao is a Engineering article available to read on EtoBox.

What is Targeting EGFR of triple-negative breast cancer enhances the therapeutic efficacy of paclitaxel- and cetuximab-conjugated nanodiamond nanocomposite about?

Breast cancer is the most common malignancy and a leading cause of cancer-related mortality among women worldwide. Triple-negative breast cancer (TNBC) is characterized by the lack of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2). However, epidermal growth factor receptor (EGFR) is highly expressed in most of the TNBCs, which may provide a potential target for EGFR targeting therapy. Nanodiamond (ND) is a carbon-based nanomaterial with several advantages, including fluorescence emission, biocompatibility, and drug delivery applications. In this study, we designed a nanocomposite by using ND conjugated with paclitaxel (PTX) and cetuximab (Cet) for targeting therapy on the EGFR-positive TNBC cells. ND-PTX inhibited cell viability and induced mitotic catastrophe in various human breast cancer cell lines (MDA-MB-231, MCF-7, and BT474); in contrast, ND alone did not induce cell death. ND-PTX inhibited the xenografted human breast tumors in nude mice. We further investigated ND-PTX-Cet drug efficacy on the TNBC of MDA-MB-231 breast cancer cells. ND-PTX-Cet could specifically bind to EGFR and enhanced the anticancer effects includin

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Author

Wei-Siang Liao; Yu Ho; Yu-Wei Lin; Emmanuel Naveen Raj; Kuang-Kai Liu; Chinpiao Chen; Xiao-Zhen Zhou; Kun-Ping Lu; Jui-I Chao

Published

2019

Language

EN

Field

Engineering (Physical Sciences)