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Genome Engineering: CRISPR vs. ZFNs/TALENs by api-318403746 is a document available to read on EtoBox.
heng, Q., et al. (2013). CRISPR/Cas9 systems have been shown to be more efficient genome editing tools than previous tools like ZFNs and TALENs. CRISPR/Cas9 uses a guide RNA to target specific DNA sequences for cleavage by Cas9 nuclease. This allows for easy knockouts and gene insertions. Some applications of CRISPR/Cas9 discussed include removing HIV from infected cells, studying cancer genes, and activating genes in stem cell research through a deactivated Cas9. While more precise than previous tools, of
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