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How much do Pseudomonas biofilms contribute to symptoms of pulmonary exacerbation in cystic fibrosis? by Donald R. VanDevanter; Jill M. Van Dalfsen is a Medicine article available to read on EtoBox.

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## Abstract Recent studies suggest that chronic __Pseudomonas aeruginosa__ lung infections in cystic fibrosis (CF) involve anaerobic biofilms, and that these biofilms are the reason chronic infections are rarely eradicated by antibiotic therapy, regardless of the in vitro susceptibility of infecting bacteria. These observations led to the development of an in vitro method for testing antibiotic susceptibility of CF clinical isolates in biofilms (Moskowitz et al., J Clin Microbiol 2004;42:1915–1922) and unearthed an apparent paradox. Antibiotics that remain cornerstones of clinical management of CF pulmonary exacerbations (e.g., beta‐lactam antibiotics) appear to have little to no activity at clinically achievable concentrations when tested in vitro against clinical __P. aeruginosa__ isolates growing in biofilms. The proven clinical efficacy of beta‐lactam antibiotics in treating exacerbations, and the selection for beta‐lactam resistance in vivo, suggest that planktonic bacteria play a significant role in pulmonary exacerbations of CF. A model of infection architecture is proposed in which biofilm and planktonic compartments each play a role in infection persistence and pulmonary e

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Author

Donald R. VanDevanter; Jill M. Van Dalfsen

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 8755-6863)

Published

2005

Language

EN

Field

Medicine (Health Sciences)