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Electrospinning and biocompatibility evaluation of biodegradable polyurethanes based on L-lysine diisocyanate and L-lysine chain extender by Jian Han; Run-Wu Cao; Bing Chen; Lin Ye; Ai-Ying Zhang; Jian Zhang; Zeng-Guo Feng is a Engineering article available to read on EtoBox.

What is Electrospinning and biocompatibility evaluation of biodegradable polyurethanes based on L-lysine diisocyanate and L-lysine chain extender about?

## Abstract A series of biodegradable polyurethanes (PUs) were synthesized using poly(ε‐caprolactone) diol (PCL) to react with L‐lysine ethyl ester diisocyanate (LDI) chain extend with L‐lysine ethyl ester (LEE) in solution of DMF. The structure was characterized by gel permeation chromatography, ^1^H‐NMR, Fourier transform infrared, and DSC analyses. Mechanical property testing showed that their tensile strength rose with increasing the hard segment content with a maximum tensile strength of 34.43 ± 1.73 MPa. The average mass loss for the hydrolytic degradation was only about 13 % in 56 days while this value for the enzymatic degradation was around 95 % in 30 days. The morphological and biomechanical characters of the tubular scaffolds electrospun from the as‐prepared PUs were also examined. As the solution concentration was varied from 10 to 18% (w/v), the fiber diameter was progressively increased, and the scaffold tensile strength was enhanced from 2.82 ± 0.16 MPa to 7.07 ± 0.44 MPa, the suture retention strength from 2.48 ± 0.33 to 8.38 ± 0.35 N, and the burst pressure strength from 72 ± 2 to 172 ± 2 kPa, all higher than those of native blood vessels. At the same time, the L‐9

Who reads Electrospinning and biocompatibility evaluation of biodegradable polyurethanes based on L-lysine diisocyanate and L-lysine chain extender?

Author

Jian Han; Run-Wu Cao; Bing Chen; Lin Ye; Ai-Ying Zhang; Jian Zhang; Zeng-Guo Feng

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1549-3296)

Published

2011

Language

EN

Field

Engineering (Physical Sciences)