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Mural Serum Response Factor (SRF) Deficiency Provides Insights into Retinal Vascular Functionality and Development by Alexander Günter; Vithiyanjali Sothilingam; Michael M. Orlich; Alfred Nordheim; Mathias W. Seeliger; Regine Mühlfriedel is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Mural Serum Response Factor (SRF) Deficiency Provides Insights into Retinal Vascular Functionality and Development about?
Serum response factor (SRF) controls the expression of muscle contraction and motility genes in mural cells (MCs) of the vasculature. In the retina, MC-SRF is important for correct angiogenesis during development and the continuing maintenance of the vascular tone. The purpose of this study was to provide further insights into the effects of MC SRF deficiency on the vasculature and function of the mature retina in __Srf^iMCKO^__ mice that carry a MC-specific deletion of __Srf__. Retinal morphology and vascular integrity were analyzed in vivo via scanning laser ophthalmoscopy (SLO), angiography, and optical coherence tomography (OCT). Retinal function was evaluated with full-field electroretinography (ERG). We found that retinal blood vessels of these mutants exhibited different degrees of morphological and functional alterations. With increasing severity, we found vascular bulging, the formation of arteriovenous (AV) anastomoses, and ultimately, a retinal detachment (RD). The associated irregular retinal blood pressure and flow distribution eventually induced hypoxia, indicated by a negative ERG waveform shape. Further, the high frequency of interocular differences in the phenotype
Who reads Mural Serum Response Factor (SRF) Deficiency Provides Insights into Retinal Vascular Functionality and Development?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Alexander Günter; Vithiyanjali Sothilingam; Michael M. Orlich; Alfred Nordheim; Mathias W. Seeliger; Regine Mühlfriedel
- Publisher
- MDPI AG
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)