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MAPK pathway activation through BRAF gene fusion in pilocytic astrocytomas; a novel oncogenic fusion gene with diagnostic, prognostic, and therapeutic potential by Judith WM Jeuken; Pieter Wesseling is a Medicine article available to read on EtoBox.
What is MAPK pathway activation through BRAF gene fusion in pilocytic astrocytomas; a novel oncogenic fusion gene with diagnostic, prognostic, and therapeutic potential about?
## Abstract Recently, a new mechanism for activation of __B‐RAF__ was identified resulting from a tandem duplication, generating a fusion protein with constitutive BRAF activity and thereby activating the MAPK pathway. Different fusion variants involving __BRAF__ and __KIAA1549__ were demonstrated, present in 80% of pilocytic astrocytomas in children. As the __KIAA1549–BRAF__ fusion gene is detected at a much lower frequency in diffuse low‐grade astrocytomas and survival was much longer than expected in the patients with a ‘non‐pilocytic’ astrocytoma carrying the fusion gene, identification of this fusion gene can be of diagnostic and prognostic value. In the near future, interference with the (fusion gene causing) activation of the MAPK signalling cascade may open new therapeutic avenues for children with pilocytic astrocytomas, as a first line of defence against tumour growth or in situations where the tumour has become refractory to other therapeutic modalities. Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. Invited Commentary for Forshew __et al__. Activation of the ERK/MAPK pathway: a signature genetic defect in posteri
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- Author
- Judith WM Jeuken; Pieter Wesseling
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)