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Oxygen-releasing Hydrogels Promote Burn Healing Under Hypoxic Conditions by Que Bai; Caiyun Zheng; Na Sun; Wenting Chen; Qian Gao; Jinxi Liu; Fangfang Hu; Tong Zhou; Yanni Zhang; Tingli Lu is a Engineering article available to read on EtoBox.
What is Oxygen-releasing Hydrogels Promote Burn Healing Under Hypoxic Conditions about?
Hypoxic nonhealing wounds are a common complication in chronic patients, and chronic hypoxia is the main reason for delayed wound healing, so local wound oxygenation may be an effective way to address this problem. Here, we proposed a system consisting of oxygen-releasing microsphere (GC) and self-healing hydrogel (QGO). QGO/GC hydrogel could promote survival, migration and tube formation of human umbilical vein endothelial cells under hypoxic conditions. Moreover, QGO/GC hydrogels exhibited biocompatibility in vitro and in vivo. The hypoxic mouse burn model further confirmed that QGO/GC hydrogel could promote tissue repair by reducing inflammation (TNF-α and IL-1β), increasing angiogenesis (CD31, VEGF and α-SMA) and collagen deposition. This study provided an effective oxygen-releasing hydrogel that could offer a simple and effective method for the clinical treatment of chronic hypoxic wounds. STATEMENT OF SIGNIFICANCE: Burn injury is caused by various exogenous factors such as friction, cold, radiations, electricity, chemicals, hot surfaces or liquids. Severe burn can damage the entire skin layer, and the healing process is delayed due to an unbalanced inflammatory response, exce
Who reads Oxygen-releasing Hydrogels Promote Burn Healing Under Hypoxic Conditions?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Que Bai; Caiyun Zheng; Na Sun; Wenting Chen; Qian Gao; Jinxi Liu; Fangfang Hu; Tong Zhou; Yanni Zhang; Tingli Lu
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Engineering (Physical Sciences)