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Microelectrode Study of the Genesis of the Monophasic Action Potential by Contact Electrode Technique by BJÖRN C. KNOLLMANN; JOSEPH TRANQUILLO; SYEVDA G. SIRENKO; CRAIG HENRIQUEZ; MICHAEL R. FRANZ is a Medicine article available to read on EtoBox.

What is Microelectrode Study of the Genesis of the Monophasic Action Potential by Contact Electrode Technique about?

**Monophasic Action Potential Genesis.** __Introduction:__ Despite widespread use of the contact electrode for recording monophasic action potentials (MAPs) in both clinical and experimental research, the mechanism underlying the genesis of the contact MAP remains unproven. The “Franz hypothesis” assumes that the MAP is driven by a current source originating at the boundary between cells depolarized by the MAP electrode pressure and normal cells immediately adjacent to it. To date, no direct experimental data exist to support this hypothesis. __Methods and Results:__ In 10 Langendorff‐perfused mouse hearts, a miniaturized MAP probe was inserted into the right ventricle (RV) and gently pressed against the endocardium of the upward‐facing RV free wall. During stable contact and stable MAP recording, KCl‐filled glass microelectrodes were lowered from above the RV to record transmembrane action potentials (TAPs) at the center of and 0.05 and 0.2 mm outside the perimeter of the MAP electrode contact site. TAPs at the center had normal resting potentials (RP) in epicardial layers (−78 ± 4 mV) but showed gradual decrease toward deeper layers, reaching a minimum RP of −23 ± 0.8 mV directly

Who reads Microelectrode Study of the Genesis of the Monophasic Action Potential by Contact Electrode Technique?

Author

BJÖRN C. KNOLLMANN; JOSEPH TRANQUILLO; SYEVDA G. SIRENKO; CRAIG HENRIQUEZ; MICHAEL R. FRANZ

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Futura Publishing Company, Inc; Blackwell Publishing Inc.; Wiley (ISSN 1540-8167)

Published

2002

Language

EN

Field

Medicine (Health Sciences)