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Recovery of 0.1 Hz microvascular skin blood flow in dysautonomic diabetic (type 2) neuropathy by using Frequency Rhythmic Electrical Modulation System (FREMS) by L. Bocchi; A. Evangelisti; M. Barrella; L. Scatizzi; M. Bevilacqua is a Medicine article available to read on EtoBox.

What is Recovery of 0.1 Hz microvascular skin blood flow in dysautonomic diabetic (type 2) neuropathy by using Frequency Rhythmic Electrical Modulation System (FREMS) about?

Synchronized oscillation of smooth muscle cells tension in arterioles is the main control system of microvascular skin blood flow. An important autogenic vasomotion activity is recognized in 0.1 Hz oscillations through power spectrum analysis of laser Doppler flowmetry. Severe dysautonomia in diabetic neuropathy is correlated with loss of 0.1 Hz vasomotor activity, hence with impaired blood microcirculation. FREMS is a novel transcutaneous electrotherapy characterized by sequences of electrical stimuli of high voltage and low pulse duration which vary both in frequency and duration. We have evaluated the changes in laser Doppler flow in the volar part of the forearm before, during and after FREMS. Normal controls (n = 10, 6 females, age range 21-39 years) demonstrated significant 0.1 Hz vasomotion power spectra at baseline conditions associated with large oscillations of adrenergic cutaneous sweat activity sampled from the hand; people with diabetes type 2 and severe dysautonomia (n = 10, 5 females, age range 63-75 years) displayed a significant decrease of 0.1 Hz vasomotion power spectra. During FREMS application we observed an increase (p < 0.05) of 0.1 Hz vasomotion power spectr

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Author

L. Bocchi; A. Evangelisti; M. Barrella; L. Scatizzi; M. Bevilacqua

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1350-4533)

Published

2010

Language

EN

Field

Medicine (Health Sciences)