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Tandem duplications of MLL and FLT3 are correlated with poor prognoses in pediatric acute myeloid leukemia: A study of the Japanese childhood AML Cooperative Study Group by Akira Shimada; Tomohiko Taki; Ken Tabuchi; Takeshi Taketani; Ryoji Hanada; Akio Tawa; Masahiro Tsuchida; Keizo Horibe; Ichiro Tsukimoto; Yasuhide Hayashi is a Medicine article available to read on EtoBox.

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## Abstract ## Background __Mixed‐lineage leukemia__ (__MLL__)‐partial tandem duplication (PTD) is associated with poor prognosis in adult acute myeloid leukemia (AML), but its relationship to pediatric AML is unknown. ## Procedure One hundred fifty‐eight newly diagnosed AML patients, including 13 FAB‐M3 and 10 Down syndrome (DS) patients, who were treated on the Japanese Childhood AML Cooperative Treatment Protocol AML 99 were analyzed for __MLL__‐PTD, as well as internal tandem duplication (ITD) and the kinase domain mutation (D835Mt) in the __FLT3__ gene. ## Results We found __MLL__‐PTD in 21 (13.3%) of 158 AML patients, but not in FAB‐M3 or DS patients. The differences between patients with and without __MLL__‐PTD were significant for 3‐year overall survival (OS) (56.3% vs. 83.2%, __P__ = 0.018), disease‐free survival (DFS) (41.7% vs. 69.6%, __P__ = 0.010), and relapse rate (RR) (54.3% vs. 27.6%, __P__ = 0.0085) of 135 AML patients excluding the FAB‐M3 and DS patients. Furthermore, ITD and D835Mt in the __FLT3__ gene were found in 17 (12.6%) and 8 (5.9%) of these 135 patients, respectively. The differences between patients with __FLT3__‐ITD and the wild‐type allele were signifi

Who reads Tandem duplications of MLL and FLT3 are correlated with poor prognoses in pediatric acute myeloid leukemia: A study of the Japanese childhood AML Cooperative Study Group?

Author

Akira Shimada; Tomohiko Taki; Ken Tabuchi; Takeshi Taketani; Ryoji Hanada; Akio Tawa; Masahiro Tsuchida; Keizo Horibe; Ichiro Tsukimoto; Yasuhide Hayashi

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)

Published

2007

Language

EN

Field

Medicine (Health Sciences)