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Pronounced Microsatellite Instability in Transitional Cell Carcinomas from Young Patients with Bladder Cancer by Mariann Christensen; Maria A. Jensen; Hans Wolf; Torben F. Ørntoft is a Medicine article available to read on EtoBox.

What is Pronounced Microsatellite Instability in Transitional Cell Carcinomas from Young Patients with Bladder Cancer about?

Microsatellites may show loss of heterozygosity as well as instability of the repeats. We examined 22 different microsatellites in 14 bladder tumours (7 grade II non-invasive, 7 grade III/IV invasive) and found altered CA repeat length compared with leukocytes, indicating instability, in several microsatellites in all tumours. Instability was significantly more frequent in low stage tumours compared with high stage tumours. The number of new bands occuring was also significantly higher in low stage tumours (median 7.2) compared with high stage tumours (median 3.3). Furthermore, patients with a disease course H1 year had significantly more unstable microsatellites (10.83) than those with a disease course F1 year (mean 8.88). Examination of biopsies from normal bladder mucosa showed no instability. In 2 cases in which selected site biopsies were taken, alterations differed from the tumours, pointing at a different clonal development. LOH was most frequent in 9p markers in low stage tumours. In a group of markers located at 2p, 17p (p53), 9q, 5q and 10p, LOH was significantly more frequent in high stage tumours. Microsatellites placed at MSH2 and MLH1 loci showed LOH in several cases,

Who reads Pronounced Microsatellite Instability in Transitional Cell Carcinomas from Young Patients with Bladder Cancer?

Author

Mariann Christensen; Maria A. Jensen; Hans Wolf; Torben F. Ørntoft

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1998

Language

EN

Field

Medicine (Health Sciences)