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Patterns and Patients’ Characteristics Associated With Use of Sodium-Glucose Cotransporter-2 Inhibitors Among Adults With Type 2 Diabetes: A Population-based Cohort Study by Dennis B. Campbell; David J.T. Campbell; Flora Au; Reed F. Beall; Paul E. Ronksley; Derek S. Chew; Yewande Ogundeji; Braden J. Manns; Brenda R. Hemmelgarn; Marcello Tonelli; Amity E. Quinn is a Medicine article available to read on EtoBox.
What is Patterns and Patients’ Characteristics Associated With Use of Sodium-Glucose Cotransporter-2 Inhibitors Among Adults With Type 2 Diabetes: A Population-based Cohort Study about?
Objectives Our aim in this study was to describe patterns and patient-level factors associated with use of sodium-glucose cotransporter-2 inhibitors (SGLT2is) among adults with diabetes being treated in Alberta, Canada. Methods Using linked administrative data sets from 2014 to 2019, we defined a retrospective cohort of adults with prevalent or incident type 2 diabetes with indications for SGLT2i use and who did not have advanced kidney disease (glomerular filtration rate <30 mL/min per 1.73 m2) or previous amputation. We describe medication dispensation patterns of SGLT2is over time in the overall cohort and among the subgroup with cardiovascular disease (CVD). Multivariable logistic regression was used to determine patients’ characteristics associated with SGLT2i use. Results Of the 341,827 patients with diabetes (mean age, 60.7 years; 45.6% female), 107,244 (31.3%) had CVD. The proportion of patients with an SGLT2i prescription increased in a linear fashion to a maximum of 10.8% (95% confidence interval [CI], 10.7% to 10.9%) of the eligible cohort by the end of the observation period (March 2019). The proportion of filled prescriptions was similar for patients with CVD (10.4%; 9
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- Author
- Dennis B. Campbell; David J.T. Campbell; Flora Au; Reed F. Beall; Paul E. Ronksley; Derek S. Chew; Yewande Ogundeji; Braden J. Manns; Brenda R. Hemmelgarn; Marcello Tonelli; Amity E. Quinn
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)