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Can I read Growth hormone response to hpGRF-40 in different forms of growth retardation and endocrine-metabolic diseases on EtoBox?
Growth hormone response to hpGRF-40 in different forms of growth retardation and endocrine-metabolic diseases by C. Pintor; S. Loche; R. Puggioni; S. G. Cella; V. Locatelli; F. Villa; R. Corda; E. E. Müller is a Medicine article available to read on EtoBox.
What is Growth hormone response to hpGRF-40 in different forms of growth retardation and endocrine-metabolic diseases about?
The effect of one of the new human pancreatic growth hormone releasing factors (hpGRFs) was assessed in children or young adults with different forms of growth retardation or endocrine-metabolic diseases. Intravenously administered synthetic hpGRF-40 (1 microgram/kg) induced a clear-cut and prompt rise in plasma growth hormone (GH) levels in 8 normal prepubertal children and a definite GH rise in 11 out of 14 children with isolated GH deficiency (IGHD) and one child with the Silver-Russel syndrome. In two out of three subjects with craniopharyngioma hpGRF-40 did not induce any plasma GH increase. In seven out of ten children with constitutional growth delay (CGD), hpGRF-40 induced a biphasic GH response, with a prompt small GH increment followed by a second, more consistent rise. Both in children with IGHD and with CGD the rise in plasma GH following hpGRF-40 was markedly lower than in controls. In children with CGD the GH response to hpGRF-40 was defective, despite the fact that in most of them the GH response to standard pharmacological stimuli was normal according to generally accepted criteria. hpGRF induced a small but sustained plasma GH rise in four hypothyroid subjects, whi
Who reads Growth hormone response to hpGRF-40 in different forms of growth retardation and endocrine-metabolic diseases?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- C. Pintor; S. Loche; R. Puggioni; S. G. Cella; V. Locatelli; F. Villa; R. Corda; E. E. Müller
- Publisher
- Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0340-6997)
- Published
- 1986
- Language
- EN
- Field
- Medicine (Health Sciences)