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Biochemical and metabolomic phenotyping in the identification of a vitamin D responsive metabotype for markers of the metabolic syndrome by Aifric O'Sullivan; Michael J. Gibney; Aine O. Connor; Brian Mion; Soniya Kaluskar; Kevin D. Cashman; Albert Flynn; Fergus Shanahan; Lorraine Brennan is a Medicine article available to read on EtoBox.

What is Biochemical and metabolomic phenotyping in the identification of a vitamin D responsive metabotype for markers of the metabolic syndrome about?

## Abstract **Scope:** Metabolic phenotyping promises to be a useful tool in human intervention studies. This study examined whether metabolic phenotyping could identify responders to vitamin D supplementation in terms of the metabolic syndrome. **Methods and results:** In a double‐blind, randomised placebo‐controlled dietary intervention subjects were assigned to receive 15 μg vitamin D~3~ or placebo daily. Serum 25‐hydroxyvitamin D (25(OH)D) and biochemical markers of the metabolic syndrome were measured at baseline and following the 4‐wk intervention. __k__‐means clustering and ^1^H‐NMR metabolomic analysis were used to explore responsive phenotypes. Vitamin D supplementation significantly increased serum 25(OH)D to an endpoint concentration of 78.1±20.0 nmol/L (__p__<0.001). There was no effect of supplementation on the measured markers of the metabolic syndrome. __k__‐means cluster analysis based on 13 biochemical markers of the metabolic syndrome and 25(OH)D concentrations revealed five discrete biomarker clusters. One of these clusters, characterised by lower serum 25(OH)D and higher levels of adipokines, showed significant responses in insulin (15% decrease), homestatic mod

Who reads Biochemical and metabolomic phenotyping in the identification of a vitamin D responsive metabotype for markers of the metabolic syndrome?

Author

Aifric O'Sullivan; Michael J. Gibney; Aine O. Connor; Brian Mion; Soniya Kaluskar; Kevin D. Cashman; Albert Flynn; Fergus Shanahan; Lorraine Brennan

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1613-4125)

Published

2011

Language

EN

Field

Medicine (Health Sciences)