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MicroRNA-572 expression in multiple sclerosis patients with different patterns of clinical progression by Roberta Mancuso; Ambra Hernis; Simone Agostini; Marco Rovaris; Domenico Caputo; Mario Clerici is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is MicroRNA-572 expression in multiple sclerosis patients with different patterns of clinical progression about?

## Background Demyelination and failure of remyelination are core mechanisms in the pathogenesis of multiple sclerosis (MS); the factor(s) modulating these processes are still mostly unknown. MicroRNA 572 (miR-572) is deregulated in MS and is suggested to targets neural cell adhesion molecule (NCAM), a glycoprotein involved in CNS reparative mechanisms. The aim of this study is to analyze miR-572 in patients with different clinical phenotypes of MS. ## Methods qPCR quantification of miR-572 isolated from serum was performed in 16 primary progressive (PP), 15 secondary progressive (SP), 31 relapsing remitting (RR) MS patients and 15 sex-and age-matched healthy controls. ## Results miR-572 expression was reduced overall in MS patients (p < 0.05) compared to HC; this miRNA was significantly upregulated in SPMS and in RRMS during disease relapse, whereas it was downregulated in PPMS and in quiescent phases of RRMS. miR-572 expression correlated with EDSS scores (R~Sp~ = 0.491; p < 0.05) independently of the clinical phenotype. The results suggest that this miRNA might be a tool that helps distinguishing between PPMS and SPMS and between relapsing and remitting phases in RRMS. ## Conclu

Who reads MicroRNA-572 expression in multiple sclerosis patients with different patterns of clinical progression?

Author

Roberta Mancuso; Ambra Hernis; Simone Agostini; Marco Rovaris; Domenico Caputo; Mario Clerici

Publisher

Springer Science and Business Media LLC

Published

2015

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)