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Can I read Streptozotocin-induced Diabetes Increases γ-Glutamyltranspeptidase Activity but Not Expression in Rat Liver on EtoBox?
Streptozotocin-induced Diabetes Increases γ-Glutamyltranspeptidase Activity but Not Expression in Rat Liver by John B. Watkins III; James E. Klaunig; Heather M. Smith; Paul Cornwell; Ruth A. Sanders is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Streptozotocin-induced Diabetes Increases γ-Glutamyltranspeptidase Activity but Not Expression in Rat Liver about?
Earlier work describing increased biliary excretion of the acetaminophen-cysteine conjugate advanced the hypothesis that streptozotocin-induced diabetes increases c-glutamyltranspeptidase (GGT) expression in Sprague-Dawley rats. To test this hypothesis, rats were divided into control, diabetic, and insulin-treated diabetic groups. Diabetes was induced by intravenous injection of 45 mg streptozotocin/kg body weight and was effectively controlled by insulin treatment in the appropriate group. Densitometric quantification demonstrated that hepatic GGT activity in diabetic rats was significantly increased when compared to normal and insulin-treated diabetic controls. Histochemical staining of liver was greater in female than in male rats, and staining increased in female rat liver as the duration of diabetes lengthened from 30 to 90 days. GGT activity was increased by diabetes in liver canalicular-enriched and basolateral-enriched membrane preparations, and it was unchanged in renal brush border-enriched membranes. Total mRNA isolated from diabetic and insulin-treated diabetic rat livers did not conclusively demonstrate an elevation of GGT mRNA relative to normal. Western blot analysis
Who reads Streptozotocin-induced Diabetes Increases γ-Glutamyltranspeptidase Activity but Not Expression in Rat Liver?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- John B. Watkins III; James E. Klaunig; Heather M. Smith; Paul Cornwell; Ruth A. Sanders
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1095-6670)
- Published
- 1998
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)