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Characterization of Cluster-assembled Nanostructured Titanium Oxide Coatings as Substrates for Protein Arrays by Roberta Carbone; Marzia De Marni; Andrea Zanardi; Simone Vinati; Emanuele Barborini; Lorenzo Fornasari; Paolo Milani is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Characterization of Cluster-assembled Nanostructured Titanium Oxide Coatings as Substrates for Protein Arrays about?

Protein microarray technologies are rapidly expanding to fulfill current needs of proteome discovery for disease management. Nanostructured materials have been shown to present interesting features when used in biological settings: nanostructured titanium oxide film (ns-TiOx), synthesized by supersonic cluster beam deposition (SCBD), has recently emerged as a biocompatible substrate in different biological assays. The ns-TiOx surface is characterized by a morphology at the nanoscale that can be tuned to modulate specific biomolecule-material interactions. Here we present a systematic characterization of ns-TiOx coatings as protein binding surfaces, comparing their performances with those of most common commercial substrates in protein and antibody microarray assays. Through a robust statistical evaluation of repeatability in terms of coefficient of variation (CV) analysis, we demonstrate that ns-TiOx can be used as reliable substrate for biochips in analytical protein microarray application.

Who reads Characterization of Cluster-assembled Nanostructured Titanium Oxide Coatings as Substrates for Protein Arrays?

Author

Roberta Carbone; Marzia De Marni; Andrea Zanardi; Simone Vinati; Emanuele Barborini; Lorenzo Fornasari; Paolo Milani

Publisher

Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0003-2697)

Published

2009

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)