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This review discusses the development and expression of human insulin genes in E. coli, leading to the first FDA-approved human insulin, Humulin, in 1982. The project began in the late 1970s, focusing on cloning and synthesizing genes for human proteins, initially starting with somatostatin before progressing to insulin. The successful production of human insulin marked a significant milestone in biotechnology, providing a scalable source of insulin for diabetics and catalyzing the growth of the biotechnolo

Author

Farid Ismail

Language

EN