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Multivariate Analysis of Several Molecular Markers and Clinicopathological Features in Postoperative Prognosis of Hepatocellular Carcinoma by Qiang Zuo; Hui Huang; Min Shi; Futing Zhang; Jiping Sun; Jianping Bin; Yulin Liao; Wangjun Liao is a Environmental Science article available to read on EtoBox.
What is Multivariate Analysis of Several Molecular Markers and Clinicopathological Features in Postoperative Prognosis of Hepatocellular Carcinoma about?
## Abstract This study was designed to assess the impact of several molecular markers and clinicopathological characteristics on postoperative survival of patients with hepatocellular carcinoma (HCC). Postoperative clinical data of 64 patients with HCC were retrospectively analyzed. __K‐ras__, __PIK3CA__, and __BRAF__ gene mutations in surgically resected specimens of the 64 patients with HCC were detected by pyrosequencing. H‐ras and XB130 protein expression was examined by immunohistochemistry. A Cox proportional hazards regression model was used for univariate and multivariate survival analyses of the clinical and pathological parameters. The mutation rates of __K‐ras__, __PIK3CA__, and __BRAF__ genes in HCC were found to be 4.69%, 1.56%, and 0%, respectively. Positive expression rate of __XB130__ and __H‐ras__ in HCC was 75.0% and 93.8%, respectively. Univariate analysis revealed that clinicopathological factors impacting postoperative prognosis of patients with HCC include clinical stage, tumor diameter, and postoperative transcatheter arterial embolization therapy for HCC. Meanwhile, multivariate analysis showed that clinical stage (relative risk [RR]: 6.420, __P__ = 0.013) a
Who reads Multivariate Analysis of Several Molecular Markers and Clinicopathological Features in Postoperative Prognosis of Hepatocellular Carcinoma?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Qiang Zuo; Hui Huang; Min Shi; Futing Zhang; Jiping Sun; Jianping Bin; Yulin Liao; Wangjun Liao
- Publisher
- Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1932-8486)
- Published
- 2011
- Language
- EN
- Field
- Environmental Science (Physical Sciences)