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What is IGF System about?

The insulin-like growth factor (IGF) system, comprising ligands, receptors, and binding proteins, plays a crucial role in growth and cancer development. Elevated serum levels of IGF-II and altered IGF binding protein levels are associated with increased cancer risk, while IGF receptors are often overexpressed in tumors, influencing cell survival and metastasis. This review discusses the structure, function, and signaling pathways of the IGF system and its implications in tumorigenesis.

Author

Tisha Tere

Language

EN