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The relationship between age, sex, egg‐count and specific antibody responses against Schistosoma mansoni antigens in a Ugandan fishing community by Cynthia W. A. Naus; Mark Booth; Frances M. Jones; Jovanice Kemijumbi; Birgitte J. Vennervald; Curtis H. Kariuki; John H. Ouma; Narcis B. Kabatereine; David W. Dunne is a Medicine article available to read on EtoBox.
What is The relationship between age, sex, egg‐count and specific antibody responses against Schistosoma mansoni antigens in a Ugandan fishing community about?
## Summary In schistosomiasis endemic areas, antibody isotype responses against __Schistosoma mansoni__ antigens vary with host age, sex and duration or intensity of infection, and are associated with susceptibility or resistance to infection. Identifying the quality and quantity of these responses is important to our understanding of the host–parasite relationship; however, the various host and parasite factors have a strong tendency to confound each other. We investigated the relationships and interactions between age, sex, faecal egg‐counts and specific antibody isotype (IgA, IgG1, IgG2, IgG3, IgG4, IgE, IgM) responses to __S. mansoni__ worm (SWA) and egg (SEA) antigens, amongst 380 individuals aged 5–59 from a fishing community from Uganda. This community was characterized by high levels of exposure, and high infection intensities, with higher infection intensities in males than in females. Multivariate anova was conducted with interaction terms between the three categorized explanatory variables. Most anti‐SWA responses increased with age, whereas anti‐SEA responses tended to decline with age, especially after puberty. IgG1‐SWA, IgG4‐SWA, IgG4‐SEA, IgE‐SWA responses increased
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- Author
- Cynthia W. A. Naus; Mark Booth; Frances M. Jones; Jovanice Kemijumbi; Birgitte J. Vennervald; Curtis H. Kariuki; John H. Ouma; Narcis B. Kabatereine; David W. Dunne
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; ScienceOpen (ISSN 1360-2276)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)