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Application of Discriminant Analysis to Differentiate Between Incorporation of Cocaine and Its Congeners Into Hair and Contamination by C. Hoelzle; F. Scheufler; M. Uhl; H. Sachs; D. Thieme is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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The requirement to differentiate between incorporation and external contamination of drugs into hair is undisputed, in particular when dealing with compounds which are administered by sniffing or inhalation (e.g. cocaine). With the aim of making this discrimination, hair samples from cocaine (COC) users (group IN) and seized cocaine samples (group OUT) were compared regarding the parameters benzoylecgonine (BZE), ecgonine methyl ester (EME), ecgonine (ECG), anhydroecgonine methyl ester (AEME), cocaethylene (CE) and norcocaine (NCOC). Since most of these compounds may be minor by-products of COC or be formed by biotransformation or chemical degradation, the stability of each substance was carefully examined. COC was found to be converted into significant amounts of BZE, EME and ECG even under mild extraction conditions, while traces of NCOC proved to be a ubiquitous by-product of COC. Cocaine positive hairs and seized cocaine samples (diluted to relevant concentrations) were equally preprocessed and analyzed by LC-MS-MS. Out of the metabolites listed above, NCOC, CE and AEME (each normalised to COC) were significantly increased in the incorporation group (i.e. hair samples from coca

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Author

C. Hoelzle; F. Scheufler; M. Uhl; H. Sachs; D. Thieme

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0379-0738)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)