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Segmentation of Heteropolymer Sequences Specifying Subsequences with Different Composition and Statistical Properties by Leonid V. Gusev; Valentina V. Vasilevskaya; Vsevolod Ju. Makeev; Pavel G. Khalatur; Alexei R. Khokhlov is a Materials Science article available to read on EtoBox.
What is Segmentation of Heteropolymer Sequences Specifying Subsequences with Different Composition and Statistical Properties about?
## Abstract We have studied the segmentation of two‐letter **__AB__** heterosequences composed of subsequences with different composition and distribution of **__A__** and **__B__** monomer units along the chain. Our approach is based on the segmentation function __S__(__k__) introduced in the present work and on the Jensen–Shannon divergence measure determined with respect to the probabilities of the lengths of uniform blocks of **__A__** and **__B__** monomer units. It is shown that the function __S__(__k__) is extremely sensitive to the sequence statistics. Even visual analysis of __S__(__k__) allows judgment on some features of sequence statistics. In particular, function __S__(__k__) is constant for random copolymers, it is an oscillating function for random block copolymers and shows monotonic growth up to some constant value for proteinlike copolymers. However, due to significant fluctuations observed for short sequences, the function __S__(__k__) can be effectively used only for segmentation of a heterosequence composed of very long subsequences. On the other hand, we find that the Jensen–Shannon divergence measure does not allow one to judge the type of statistics, but is
Who reads Segmentation of Heteropolymer Sequences Specifying Subsequences with Different Composition and Statistical Properties?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Leonid V. Gusev; Valentina V. Vasilevskaya; Vsevolod Ju. Makeev; Pavel G. Khalatur; Alexei R. Khokhlov
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1022-1344)
- Published
- 2003
- Language
- EN
- Field
- Materials Science (Physical Sciences)