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Can I read Vinblastine-induced Aggregates of Smooth Endoplasmic Reticulum in Proximal Tubular Cells of Rat Kidney on EtoBox?
Vinblastine-induced Aggregates of Smooth Endoplasmic Reticulum in Proximal Tubular Cells of Rat Kidney by Dr. Greta E. Tyson; Ruth Ellen Bulger is a Medicine article available to read on EtoBox.
What is Vinblastine-induced Aggregates of Smooth Endoplasmic Reticulum in Proximal Tubular Cells of Rat Kidney about?
## Abstract Vinblastine sulfate was given to adult rats by two tail‐vein injections. After a total treatment time of five hours, kidney cortex was fixed and prepared for examination by routine transmission electron microscopy. Cells of proximal convoluted tubules from treated animals were found to contain focal aggregates of smooth endoplasmic reticulum. Such aggregates were not normally present in cells of control animals. The smooth membranes of these aggregates bear some resemblance to phenobarbital‐induced proliferations of smooth endoplasmic reticulum described in liver cells by many previous investigators, and the suggestion is made that the aggregates described here may reflect a vinblastine‐induced increase within proximal tubule cells of enzymes which function in drug metabolism. That molecules of vinblastine actually entered proximal tubule cells was evidenced by the fact that cytoplasmic microtubules were greatly reduced in number and paracrystals of microtubular protein were occasionally observed.
Who reads Vinblastine-induced Aggregates of Smooth Endoplasmic Reticulum in Proximal Tubular Cells of Rat Kidney?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Dr. Greta E. Tyson; Ruth Ellen Bulger
- Publisher
- Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0002-9106)
- Published
- 1974
- Language
- EN
- Field
- Medicine (Health Sciences)