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Cell signalling and gene expression mediated by RET tyrosine kinase by K Kurokawa; K. Kawai; M. Hashimoto; Y. Ito; M. Takahashi is a Medicine article available to read on EtoBox.

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**Abstract.** Kurokawa K, Kawai K, Hashimoto M, Ito Y, Takahashi M (Nagoya University Graduate School of Medicine, Showa‐ku, Nagoya, Japan). Cell signalling and gene expression mediated by RET tyrosine kinase (Minisymposium). __J Intern Med__ 2003; **253:** 627–633. Germline mutations of the __RET__ proto‐oncogene cause multiple endocrine neoplasia (MEN) 2A or 2B by different mechanisms. As is the case for other receptor tyrosine kinases, mutant RET recruits a variety of signalling molecules via phosphorylated tyrosine residues present in the kinase domain and carboxy‐terminal tail. As we previously reported, the signaling via phosphorylated tyrosine 1062 plays a crucial role in the transforming activities of both RET‐MEN2A and RET‐MEN2B mutant protein. Interestingly, this single tyrosine residue represents a binding site for several signalling molecules including SHC, Enigma, SNT/FRS2, DOK and IRS1 and is responsible for activation of the RAS/ERK, PI3‐K/AKT, JNK, p38MAPK and ERK5 signalling pathways. Amongst these, the PI3‐K/AKT and JNK pathways appeared to be more strongly activated in the cells expressing RET‐MEN2B than in the cells expressing RET‐MEN2A, suggesting the possibili

Who reads Cell signalling and gene expression mediated by RET tyrosine kinase?

Author

K Kurokawa; K. Kawai; M. Hashimoto; Y. Ito; M. Takahashi

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0954-6820)

Published

2003

Language

EN

Field

Medicine (Health Sciences)