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Recovery of protein synthesis in tolerance-induced hippocampal CA1 neurons after transient forebrain ischemia by Shigeru Furuta; Shinsuke Ohta; Takao Hatakeyama; Ko Nakamura; Saburo Sakaki is a Medicine article available to read on EtoBox.

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Protein synthesis at various recirculation times after 5-min transient forebrain ischemia was evaluated in gerbil hippocampal CA1 pyramidal neurons that had acquired tolerance to delayed-type ischemic injury. Evaluation was performed by observing polyribosomes under electron microscopy, and by [14C] leucine autoradiography. Hippocampal CA1 pyramidal neurons in the gerbils acquired stable and reproducible tolerance to delayed-type ischemic injury subsequent to a 5-rain ischemia by pretreatment that consisted of loading two 2-min ischemic periods at a 1-day interval, followed by 48 h of recirculation. During the early phase following the 5-rain ischemia, polyribosomal disaggregation, loss of dendritic microtubules, and significant suppression of radiolabeled leucine incorporation were observed in the tolerance-induced CA1 neurons as well as in the nontolerance-induced neurons. While these findings persisted in the non-tolerance-induced neurons throughout the duration of the experiment, most of the toleranceinduced neurons demonstrated reaggregation of cytosomal ribosomes, increase in the number of dendritic microtubules, and restoration of impaired amino acid incorporation 24 h after

Who reads Recovery of protein synthesis in tolerance-induced hippocampal CA1 neurons after transient forebrain ischemia?

Author

Shigeru Furuta; Shinsuke Ohta; Takao Hatakeyama; Ko Nakamura; Saburo Sakaki

Publisher

Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0001-6322)

Published

1993

Language

EN

Field

Medicine (Life Sciences)